Description
Product Characteristics: FUNCTION: LIN7A: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Subcellular location: Cell membrane, Peripheral membrane protein. Basolateral cell membrane, Peripheral membrane protein. Cell junction. Cell junction âÄ° synapse âÄ° postsynaptic cell membrane âÄ° postsynaptic density, Peripheral membrane protein. Cell junction âÄ° tight junction. Cell junction âÄ° synapse âÄ° synaptosome. Note: Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells. Tissue specificity: Expressed in brain, testis, kidney, placenta and liver.,Cell Adhesion Proteins,LIN7A, Protein lin-7 homolog A, Lin-7A, Mammalian lin-seven protein 1, MALS-1, Tax interaction protein 33, TIP-33, Vertebrate lin-7 homolog 1, Veli-1, MALS1, VELI1. LIN7B, Protein lin-7 homolog B, Lin-7B, Mammalian lin-seven protein 2, MALS2, VELI1. LIN7C, Protein lin-7 homolog C, Lin-7C, Mammalian lin-seven protein 3, MALS3, VELI3.
Target Information: may mediate the formation of cell-cell junctions